NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer | Zendy

Soham D. Puvvada | Zendy; William K. Funkhouser | Zendy; Kevin G. Greene | Zendy; Allison M. Deal | Zendy; Haitao Chu | Zendy; Albert S. Baldwin | Zendy; Joel E. Tepper | Zendy; Bert H. O’Neil | Zendy

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NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer

Author(s) -

Soham D. Puvvada,

William K. Funkhouser,

Kevin G. Greene,

Allison M. Deal,

Haitao Chu,

Albert S. Baldwin,

Joel E. Tepper,

Bert H. O’Neil

Publication year - 2010

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000313697

Subject(s) - colorectal cancer , medicine , primary tumor , lymph node , tissue microarray , carcinogenesis , proportional hazards model , oncology , pathology , intestinal mucosa , tumor progression , metastasis , immunohistochemistry , cancer , cancer research

NF-kappaB is an antiapoptotic transcription factor that has been shown to be a mediator of treatment resistance. Bcl-3 is a regulator of NF-kappaB that may play a role in oncogenesis. The goal of this study was to correlate the activation status of NF-kappaB and Bcl-3 with clinical outcome in a group of patients with metastatic colorectal cancer (CRC).

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