Cooperative Activation of CCL5 Expression by TLR3 and Tumor Necrosis Factor-α or Interferon-γ through Nuclear Factor-ĸB or STAT-1 in Airway Epithelial Cells | Zendy

Tetsuya Homma | Zendy; Satoshi Matsukura | Zendy; Takashi Hirose | Zendy; Tsukasa Ohnishi | Zendy; Teruaki Kimura | Zendy; Masatsugu Kurokawa | Zendy; Koushi Ieki | Zendy; Miho Odaka | Zendy; Shintaro Suzuki | Zendy; Shin Watanabe | Zendy; Masayuki Sato | Zendy; Mio Kawaguchi | Zendy; Robert P. Schleimer | Zendy; Mitsuru Adachi | Zendy

Open Access

Cooperative Activation of CCL5 Expression by TLR3 and Tumor Necrosis Factor-α or Interferon-γ through Nuclear Factor-ĸB or STAT-1 in Airway Epithelial Cells

Author(s) -

Tetsuya Homma,

Satoshi Matsukura,

Takashi Hirose,

Tsukasa Ohnishi,

Teruaki Kimura,

Masatsugu Kurokawa,

Koushi Ieki,

Miho Odaka,

Shintaro Suzuki,

Shin Watanabe,

Masayuki Sato,

Mio Kawaguchi,

Robert P. Schleimer,

Mitsuru Adachi

Publication year - 2010

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000312120

Subject(s) - ccl5 , microbiology and biotechnology , biology , tlr3 , tumor necrosis factor alpha , immunology , toll like receptor , immune system , t cell , il 2 receptor , innate immune system

CCL5/RANTES contributes to prolonged eosinophilic inflammation and asthma exacerbation after a viral infection. We studied the mechanism of CCL5 expression using viral product double-stranded RNA (dsRNA), a ligand of Toll-like receptor 3 (TLR3), and inflammatory cytokines in airway epithelial cells.

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