Malignant Profile Detected by CT Angiographic Information Predicts Poor Prognosis despite Thrombolysis within Three Hours from Symptom Onset | Zendy

Volker Puetz | Zendy; Imanuel Dzialowski | Zendy; Michael D. Hill | Zendy; Nikolai Steffenhagen | Zendy; Shelagh B. Coutts | Zendy; Christine O’Reilly | Zendy; Andrew M. Demchuk | Zendy

Open Access

Malignant Profile Detected by CT Angiographic Information Predicts Poor Prognosis despite Thrombolysis within Three Hours from Symptom Onset

Author(s) -

Volker Puetz,

Imanuel Dzialowski,

Michael D. Hill,

Nikolai Steffenhagen,

Shelagh B. Coutts,

Christine O’Reilly,

Andrew M. Demchuk

Publication year - 2010

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000311079

Subject(s) - medicine , thrombolysis , interquartile range , modified rankin scale , stroke (engine) , intracerebral hemorrhage , hematoma , radiology , perfusion scanning , angiography , thrombus , cardiology , perfusion , ischemia , ischemic stroke , subarachnoid hemorrhage , mechanical engineering , myocardial infarction , engineering

A malignant profile of early brain ischemia has been demonstrated in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) trial. Patients with a malignant profile had a low chance for an independent functional outcome despite thrombolysis within 3-6 h. We sought to determine whether CT angiography (CTA) could identify a malignant imaging profile within 3 h from symptom onset.

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