Open AccessA High-Sucrose Isocaloric Pair-Fed Model Induces Obesity and Impairs NDUFB6 Gene Function in Rat Adipose Tissue
Author(s) -
Almudena Lomba,
Fermı́n I. Milagro,
Diego F. García-Díaz,
Javier Campión,
Florencio Marzo,
Jean Martínez
Publication year - 2009
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000308465
Subject(s) - endocrinology , medicine , adipose tissue , adiponectin , insulin resistance , biology , weight gain , dietary sucrose , fatty liver , carbohydrate metabolism , obesity , body weight , disease
Changes in dietary macronutrient content are involved in altered energy metabolism and obesity development. However, there are controversial views about the obesogenic effects of high-sucrose (HS) diets, which usually lead to obesity and insulin resistance but are sometimes associated with reduced weight gain. The aim of this study was to investigate the effect of consumption of a pair-fed HS diet on weight gain and energy homeostasis in rats, as well as to assess the effects on expression of the NADH dehydrogenase (ubiquinone) 1beta subcomplex 6 (NDUFB6) gene in adipose tissue.