Open AccessDefective Circulating CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>CD127<sup>low</sup> Regulatory T-cells in Patients with Chronic Heart Failure
Author(s) -
Tingting Tang,
Yongjie Ding,
Yuhua Liao,
Lei Yu,
Hong Xiao,
JiaZhao Xie,
Jing Yuan,
Zihua Zhou,
Mengyang Liao,
Rui Yao,
Yan Cheng,
Xiang Cheng
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000303050
Subject(s) - foxp3 , il 2 receptor , interleukin 7 receptor , peripheral blood mononuclear cell , immune system , medicine , pathogenesis , regulatory t cell , endocrinology , flow cytometry , ejection fraction , immunology , heart failure , biology , t cell , in vitro , biochemistry
Increasing evidences confirm the role of immune activation in the pathogenesis of chronic heart failure (CHF). Regulatory T cells appear central to the control of immune homeostasis. We assessed the hypothesis that the circulating frequency and function of CD4+CD25+ Foxp3+CD127(low) T regulatory cells (Tregs) would be deranged in patients with CHF.