Defective Circulating CD4+CD25+Foxp3+CD127low Regulatory T-cells in Patients with Chronic Heart Failure | Zendy

Tingting Tang | Zendy; Yingjun Ding | Zendy; Yuhua Liao | Zendy; Xianjun Yu | Zendy; Hong Xiao | Zendy; Jiang-jiao Xie | Zendy; Jing Yuan | Zendy; Zihua Zhou | Zendy; Mengyang Liao | Zendy; Rui Yao | Zendy; Yan Cheng | Zendy; Xiang Cheng | Zendy

Open Access

Defective Circulating CD4+CD25+Foxp3+CD127low Regulatory T-cells in Patients with Chronic Heart Failure

Author(s) -

Tingting Tang,

Yingjun Ding,

Yuhua Liao,

Xianjun Yu,

Hong Xiao,

Jiang-jiao Xie,

Jing Yuan,

Zihua Zhou,

Mengyang Liao,

Rui Yao,

Yan Cheng,

Xiang Cheng

Publication year - 2010

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000303050

Subject(s) - foxp3 , il 2 receptor , interleukin 7 receptor , peripheral blood mononuclear cell , immune system , medicine , pathogenesis , regulatory t cell , endocrinology , flow cytometry , ejection fraction , immunology , heart failure , biology , t cell , in vitro , biochemistry

Increasing evidences confirm the role of immune activation in the pathogenesis of chronic heart failure (CHF). Regulatory T cells appear central to the control of immune homeostasis. We assessed the hypothesis that the circulating frequency and function of CD4+CD25+ Foxp3+CD127(low) T regulatory cells (Tregs) would be deranged in patients with CHF.

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