Open AccessThe Action of Small GTPases Rab11 and Rab25 in Vesicle Trafficking During Cell Migration
Author(s) -
Daniel S. Kessler,
Gianna-Carina Gruen,
Dominik Heider,
Jessica Morgner,
Henning Reis,
Kurt Werner Schmid,
Verena Jendrossek
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000295249
Subject(s) - vesicle , gtpase , microbiology and biotechnology , vesicular transport protein , cell migration , cell , hela , small gtpase , fibronectin , chemistry , biology , biochemistry , signal transduction , membrane , extracellular matrix
The closely related GTPases Rab11 and Rab25 promote cell migration by regulating vesicular transport and recycling of surface receptors. Rab25 carries a constitutively activating mutation in its GTPase domain. Increased expression of Rab25 has been associated with the aggressiveness of migrating tumor cells. Here, we aimed to elucidate potential differences in the role of those two GTPases in vesicle trafficking during cell migration.