Open AccessPrenatal Cytogenetic Diagnosis of 1,400 Consecutive Amniocenteses
Author(s) -
T J Mathews,
Dipesh Navsaria,
Ram S. Verma
Publication year - 1992
Publication title -
gynecologic and obstetric investigation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 63
eISSN - 1423-002X
pISSN - 0378-7346
DOI - 10.1159/000292741
Subject(s) - chromosomal abnormality , prenatal diagnosis , chromosomal translocation , chromosome abnormality , obstetrics , medicine , pregnancy , incidence (geometry) , fetus , abnormality , trisomy , down syndrome , amniocentesis , gynecology , karyotype , biology , genetics , chromosome , physics , optics , psychiatry , gene
We report on the incidence of chromosomal abnormalities in 1,400 amniocenteses. Thirty-one cases (2.21%) were found to have various types of chromosomal abnormality. The majority of abnormal cases (54.84%) were trisomies. All individuals with trisomic fetuses chose to terminate the pregnancy with the exception of one who gave birth to a Down's syndrome child. However, fetuses with apparently balanced translocations were phenotypically normal at birth.