Frequent Overexpression of p53 in Dysgerminoma of the Ovary | Zendy

J. Dietl | Zendy; H.-P. Horny | Zendy; E. Kaiserling | Zendy

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Frequent Overexpression of p53 in Dysgerminoma of the Ovary

Author(s) -

J. Dietl,

H.-P. Horny,

E. Kaiserling

Publication year - 1994

Publication title -

gynecologic and obstetric investigation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.631

H-Index - 63

eISSN - 1423-002X

pISSN - 0378-7346

DOI - 10.1159/000292543

Subject(s) - dysgerminoma , ovary , immunohistochemistry , pathology , immature teratoma , biology , monoclonal antibody , ovarian tumor , ovarian cancer , cancer , cancer research , medicine , antibody , germ cell tumors , chemotherapy , endocrinology , immunology , genetics

The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-1. All the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10-50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.

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