Open AccessKininase I Activity in Human Fluids and Tissues of the Urogenital Tract
Author(s) -
Dirk Hendriks,
Simon Scharpé,
K. Van Camp,
M. Van Sande
Publication year - 1987
Publication title -
urologia internationalis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.771
H-Index - 53
eISSN - 1423-0399
pISSN - 0042-1138
DOI - 10.1159/000281862
Subject(s) - genitourinary system , medicine , hyperplasia , prostate , urinary system , arginine , kidney , enzyme , urology , endocrinology , biochemistry , chemistry , cancer , amino acid
Kininase I (EC 3.4.17.3) activity has been determined in human fluids and tissues of the urogenital tract. Benzoyl-glycyl-L-arginine and benzoyl-glycyl-L-lysine were used as substrates. The cleaved benzoyl-glycine was measured by means of high performance liquid chromatography. Results obtained showed a high enzymatic activity for kidney cortex. Normal prostate, benign prostatic hyperplasia and prostatic adenocarcinoma showed similar enzymic values. The activity of kininase I was higher in normal serum than in the tissues studied.