Kidneys of Alb/TGF-β1 Transgenic Mice Are Deficient in Retinoic Acid and Exogenous Retinoic Acid Shows Dose-Dependent Toxicity | Zendy

Qihe Xu | Zendy; Bruce M. Hendry | Zendy; Malcolm Maden | Zendy; Huiyan Lü | Zendy; Yuen Fei Wong | Zendy; Alexandra C Rankin | Zendy; Mazhar Noor | Zendy; Jeffrey B. Kopp | Zendy

Open Access

Kidneys of Alb/TGF-β<sub>1</sub> Transgenic Mice Are Deficient in Retinoic Acid and Exogenous Retinoic Acid Shows Dose-Dependent Toxicity

Author(s) -

Qihe Xu,

Bruce M. Hendry,

Malcolm Maden,

Huiyan Lü,

Yuen Fei Wong,

Alexandra C Rankin,

Mazhar Noor,

Jeffrey B. Kopp

Publication year - 2010

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000276587

Subject(s) - medicine , endocrinology , ctgf , retinoic acid , kidney , fibrosis , transforming growth factor , transgene , genetically modified mouse , biology , growth factor , chemistry , biochemistry , receptor , gene

Alb/TGF-beta(1) transgenic mice overexpress active transforming growth factor-beta(1) (TGF-beta(1)) in the liver, leading to increased circulating levels of the cytokine and progressive renal fibrosis. This study was designed to explore if exogenous all-trans retinoic acid (tRA) prevents renal fibrosis in this animal model.

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