Open AccessKidneys of Alb/TGF-β<sub>1</sub> Transgenic Mice Are Deficient in Retinoic Acid and Exogenous Retinoic Acid Shows Dose-Dependent Toxicity
Author(s) -
Qihe Xu,
Bruce M. Hendry,
Malcolm Maden,
Huiyan Lü,
Yuen Fei Wong,
Alexandra C Rankin,
Mazhar Noor,
Jeffrey B. Kopp
Publication year - 2010
Publication title -
nephron. experimental nephrology
Language(s) - English
Resource type - Journals
ISSN - 1660-2129
DOI - 10.1159/000276587
Subject(s) - medicine , endocrinology , ctgf , retinoic acid , kidney , fibrosis , transforming growth factor , transgene , genetically modified mouse , biology , growth factor , chemistry , biochemistry , receptor , gene
Alb/TGF-beta(1) transgenic mice overexpress active transforming growth factor-beta(1) (TGF-beta(1)) in the liver, leading to increased circulating levels of the cytokine and progressive renal fibrosis. This study was designed to explore if exogenous all-trans retinoic acid (tRA) prevents renal fibrosis in this animal model.