Open AccessA Proteomic Approach to Determine Changes in Proteins Involved in the Myocardial Metabolism in Left Ventricles of Spontaneously Hypertensive Rats
Author(s) -
José J. Zamorano-León,
Javier Modrego,
Petra J. Mateos-Cáceres,
Carlos Macaya,
Beatriz Martín-Fernández,
María Miana,
Natalia de las Heras,
Victoria Cachofeiro,
Vicente Lahera,
Antonio LópezFarré
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000276567
Subject(s) - glycolysis , beta oxidation , citric acid cycle , medicine , oxidative phosphorylation , citrate synthase , triosephosphate isomerase , endocrinology , pyruvate dehydrogenase complex , mitochondrion , biochemistry , chemistry , ventricle , biology , enzyme
Different works have suggested that in the hypertrophied heart the energy metabolic pathway shifts to glycolysis. Our aim was to evaluate using proteomics the expression of proteins associated with different energetic metabolic pathways in hypertrophied left ventricles of spontaneously hypertensive rats (SHR).