Open AccessP2X<sub>1</sub> and P2X<sub>3</sub> Purinergic Receptors Differentially Modulate the Inflammatory Response in Human Osteoarthritic Synovial Fibroblasts
Author(s) -
Katia Varani,
Monica De Mattei,
Fabrizio Vincenzi,
Alice Tosi,
Martina Targa,
Federica Francesca Masieri,
Agnese Pellati,
Leo Massari,
Pier Andrea Borea
Publication year - 2010
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000276565
Subject(s) - purinergic receptor , receptor , purinergic signalling , inflammation , microbiology and biotechnology , medicine , endocrinology , biology , chemistry , neuroscience , cancer research , agonist , adenosine receptor
P2X receptors are membrane ion channels activated by extracellular adenosine 5'-triphosphate (ATP) which contribute to various physiological processes. The present study describes in synovial fibroblasts (SFs) obtained from osteoarthritis (OA) patients and in SW 982 cells derived from human synovial sarcoma a pharmacological characterization of P2X(1) and P2X(3) receptors implicated in the modulation of inflammatory processes in joint diseases.