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AIM: We aimed to determine the inter- and intra-observer variabilities between breast radiologists and a general radiologist in categorizing mammographic lesions using the Breast Imaging Reporting and Data System (BI-RADS), and to evaluate the effects of the histopathologic results on the variability.  METHODS: Mammograms from 142 women who underwent biopsy were evaluated. 3 breast radiologists (2 with &gt;10 years experience and 1 with 1 year experience) and 1 general radiologist retrospectively reviewed mammograms twice within an 8-week interval. Inter- and intra-observer variabilities were assessed with Cohen's kappa statistic, and the positive predictive value for final assessments was calculated.  RESULTS: The intra-observer variability for mass and calcification assessments was moderate to almost perfect (kappa values: 0.41-1) for breast imagers and was fair to substantial for the general radiologist (kappa values: 0.21-0.8). Inter-observer agreement between the breast imagers was higher than between the breast and general radiologists. There was no apparent difference in agreement between observers for malignant and benign subgroups.  CONCLUSIONS: The differences in intra- and inter-observer agreement between the breast imagers and the general radiologist affirm the utility of the BI-RADS lexicon. The histopathologic results of the lesions do not affect the agreement. BI-RADS is a simple and adequate tool for assessing mammograms, even after only 1 year of training.

Observer Variability of the Breast Imaging Reporting and Data System (BI-RADS) Lexicon for Mammography