Open AccessReversible Ductus Arteriosus Constriction due to Maternal Indomethacin after Fetal Intervention for Hypoplastic Left Heart Syndrome with Intact/Restrictive Atrial Septum
Author(s) -
Mélanie Vogel,
Louise WilkinsHaug,
Doff B. McElhinney,
Audrey C. Marshall,
Carol B. Benson,
Virginia Silva,
Wayne Tworetzky
Publication year - 2009
Publication title -
fetal diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 60
eISSN - 1421-9964
pISSN - 1015-3837
DOI - 10.1159/000268290
Subject(s) - medicine , ductus arteriosus , constriction , hypoplastic left heart syndrome , cardiology , fetus , hypoplasia , heart disease , surgery , pregnancy , biology , genetics
Fetal cardiac intervention (FCI) has been performed at our center in selected fetuses with complex congenital heart disease since 2000. Most interventions are performed in fetuses with a ductus arteriosus (DA)-dependent circulation. Indomethacin promotes closure of the DA in newborns and in fetal life, a potentially life threatening complication in fetuses with ductus-dependent congenital heart disease.