Open AccessClara Cell Protein Expression in Human Neonates During Respiratory Distress Syndrome
Author(s) -
Joel Arias-Martínez,
Miguel Palacios-Sánchez,
Dagoberto Delgado-Franco,
José Guzmán-Bárcenas,
Ethel Garcı́a-Latorre,
Limei Zhang,
Claudine Irles
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000264417
Subject(s) - respiratory distress , immunoprecipitation , medicine , ards , gene isoform , lung , immunology , pulmonary surfactant , inflammation , biology , antibody , gene , biochemistry , anesthesia
Clara cell protein (cc-10) has been shown to negatively regulate inflammation, protect pulmonary surfactant from degradation in the lung, and administration of this recombinant protein improves the condition of infant respiratory distress syndrome (iRDS), a disease that occurred mainly in preterm infants. In view of the possibility that altered expression of cc-10 might regulate its protective function, we attempted to characterize this protein in infants with iRDS.