Open AccessEvidence of Interaction between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-Related Phenotypes
Author(s) -
Stéphanie-May Ruchat,
Cathy E. Elks,
Ruth J.F. Loos,
MarieClaude Vohl,
S. John Weisnagel,
Tuomo Rankinen,
Claude Bouchard,
Louis Pérusse
Publication year - 2009
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000259341
Subject(s) - single nucleotide polymorphism , glucose homeostasis , tcf7l2 , endocrinology , medicine , type 2 diabetes , snp , biology , insulin , diabetes mellitus , insulin resistance , genetics , gene , genotype
Genome-wide association studies have led to the identification of several susceptibility genes for type 2 diabetes mellitus (T2DM). The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake.