Parathyroid Hormone-Related Protein (PTHrP)-Dependent Regulation of bcl-2 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 in Coronary Endothelial Cells | Zendy

Charlotte Conzelmann | Zendy; Gabriela KrastevaChrist | Zendy; Kerstin Weber | Zendy; Wolfgang Kummer | Zendy; KlausDieter Schlüter | Zendy

Open Access

Parathyroid Hormone-Related Protein (PTHrP)-Dependent Regulation of bcl-2 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 in Coronary Endothelial Cells

Author(s) -

Charlotte Conzelmann,

Gabriela KrastevaChrist,

Kerstin Weber,

Wolfgang Kummer,

KlausDieter Schlüter

Publication year - 2009

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000257492

Subject(s) - tissue inhibitor of metalloproteinase , metalloproteinase , medicine , matrix metalloproteinase , endocrinology , parathyroid hormone , hormone , chemistry , microbiology and biotechnology , biology , calcium

An increased susceptibility of micro-vascular endothelial cells to apoptosis is considered to be an initial event leading to atherosclerosis. Parathyroid hormone-related peptide (PTHrP) is known to protect endothelial cells against apoptosis by the regulation of the anti-apoptotic gene bcl-2. As tissue inhibitor of metalloproteinase (TIMP-1) expression is regulated by bcl-2, we hypothesized that endothelial expression of PTHrP also regulates the expression of TIMP-1.

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