Open AccessParathyroid Hormone-Related Protein (PTHrP)-Dependent Regulation of bcl-2 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 in Coronary Endothelial Cells
Author(s) -
Charlotte Conzelmann,
Gabriela Krasteva,
Kerstin Weber,
Wolfgang Kummer,
KlausDieter Schlüter
Publication year - 2009
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000257492
Subject(s) - tissue inhibitor of metalloproteinase , metalloproteinase , medicine , matrix metalloproteinase , endocrinology , parathyroid hormone , hormone , chemistry , microbiology and biotechnology , biology , calcium
An increased susceptibility of micro-vascular endothelial cells to apoptosis is considered to be an initial event leading to atherosclerosis. Parathyroid hormone-related peptide (PTHrP) is known to protect endothelial cells against apoptosis by the regulation of the anti-apoptotic gene bcl-2. As tissue inhibitor of metalloproteinase (TIMP-1) expression is regulated by bcl-2, we hypothesized that endothelial expression of PTHrP also regulates the expression of TIMP-1.