Open AccessAssociation of Fatty Acid Desaturase Gene Polymorphisms with Blood Lipid Essential Fatty Acids and Perinatal Depression among Canadian Women: A Pilot Study
Author(s) -
Lin Xie,
Sheila M. Innis
Publication year - 2009
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000255636
Subject(s) - fads2 , docosahexaenoic acid , medicine , endocrinology , fatty acid desaturase , postpartum depression , blood lipids , single nucleotide polymorphism , fatty acid , polyunsaturated fatty acid , biology , biochemistry , cholesterol , pregnancy , genetics , genotype , gene
The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 contribute to variability in blood lipid fatty acids. Altered n-6 and n-3 fatty acids have been related to perinatal depression (PPD).