Association of Fatty Acid Desaturase Gene Polymorphisms with Blood Lipid Essential Fatty Acids and Perinatal Depression among Canadian Women: A Pilot Study | Zendy

Lin Xie | Zendy; Sheila M. Innis | Zendy

Open Access

Association of Fatty Acid Desaturase Gene Polymorphisms with Blood Lipid Essential Fatty Acids and Perinatal Depression among Canadian Women: A Pilot Study

Author(s) -

Lin Xie,

Sheila M. Innis

Publication year - 2009

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 30

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000255636

Subject(s) - fads2 , docosahexaenoic acid , medicine , endocrinology , fatty acid desaturase , postpartum depression , blood lipids , single nucleotide polymorphism , fatty acid , polyunsaturated fatty acid , biology , biochemistry , cholesterol , pregnancy , genetics , genotype , gene

The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 contribute to variability in blood lipid fatty acids. Altered n-6 and n-3 fatty acids have been related to perinatal depression (PPD).

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