Selective Growth Inhibition of Cancer Cells by L-Methioninase-Containing Fusion Protein Targeted to the Urokinase Receptor | Zendy

Naveen R. Palwai | Zendy; Xiao-Ping Zang | Zendy; Roger G. Harrison | Zendy; Doris M. Benbrook | Zendy; J. Thomas Pento | Zendy

Open Access

Selective Growth Inhibition of Cancer Cells by <i>L</i>-Methioninase-Containing Fusion Protein Targeted to the Urokinase Receptor

Author(s) -

Naveen R. Palwai,

Xiao-Ping Zang,

Roger G. Harrison,

Doris M. Benbrook,

J. Thomas Pento

Publication year - 2009

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000242997

Subject(s) - cell growth , fusion protein , cell culture , growth inhibition , pancreatic cancer , cancer research , cancer cell , microbiology and biotechnology , ovarian cancer , biology , in vitro , cancer , recombinant dna , biochemistry , genetics , gene

We have reported the development of a novel fusion protein (FP) consisting of an amino-terminal fragment of urokinase linked to the amino terminus of the enzyme L-methioninase (L-M). The present study compared the effect of this novel FP on the proliferation of human ovarian, skin, breast endometrial and pancreatic cancer cell lines.

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