Open AccessSelective Growth Inhibition of Cancer Cells by <i>L</i>-Methioninase-Containing Fusion Protein Targeted to the Urokinase Receptor
Author(s) -
Naveen R. Palwai,
Xiao Ping Zang,
Roger G. Harrison,
Doris M. Benbrook,
J. Thomas Pento
Publication year - 2009
Publication title -
pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.51
H-Index - 59
eISSN - 1423-0313
pISSN - 0031-7012
DOI - 10.1159/000242997
Subject(s) - cell growth , fusion protein , cell culture , growth inhibition , pancreatic cancer , cancer research , cancer cell , microbiology and biotechnology , ovarian cancer , biology , in vitro , cancer , recombinant dna , biochemistry , genetics , gene
We have reported the development of a novel fusion protein (FP) consisting of an amino-terminal fragment of urokinase linked to the amino terminus of the enzyme L-methioninase (L-M). The present study compared the effect of this novel FP on the proliferation of human ovarian, skin, breast endometrial and pancreatic cancer cell lines.