Changes in the Production of Nitric Oxide and Superoxide by Inflammatory Cells in Liver Cirrhosis | Zendy

E. Masini | Zendy; Laura Mugnai | Zendy; Marco Foschi | Zendy; Giacomo Laffi | Zendy; Paolo Geñtilini | Zendy; P. F. Mannaioni | Zendy

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Changes in the Production of Nitric Oxide and Superoxide by Inflammatory Cells in Liver Cirrhosis

Author(s) -

E. Masini,

Laura Mugnai,

Marco Foschi,

Giacomo Laffi,

Paolo Geñtilini,

P. F. Mannaioni

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236975

Subject(s) - zymosan , superoxide , cirrhosis , nitric oxide , immunology , stimulation , platelet , opsonin , nitric oxide synthase , granulocyte , medicine , chemistry , endocrinology , phagocytosis , biochemistry , in vitro , enzyme

Superoxide (O2-) and nitric oxide (NO) production by polymorphonuclear leukocyte (PMNs) and monocytes in patients with liver cirrhosis were evaluated. PMNs obtained from cirrhotic patients were less effective than those from controls in producing O2- after stimulation with opsonized zymosan, while they were more effective in producing NO, as shown by the inhibition of platelet aggregation and by the increase in cGMP content. NO synthase activity was higher in leukocytes from cirrhotic patients than in controls. A correlation was found between the cardiac index and the observed changes in the inflammatory cells.

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