Effects of lnterleukin-4 or Stem Cell Factor on Mast Cell Mediator Release and Cytokine Gene Expression | Zendy

John W. Coleman | Zendy; Mark G. Buckley | Zendy; Alison Taylor | Zendy; Edwin M. Banks | Zendy; C.M.M. Williams | Zendy; M.R. Holliday | Zendy; J Thompson | Zendy

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Effects of lnterleukin-4 or Stem Cell Factor on Mast Cell Mediator Release and Cytokine Gene Expression

Author(s) -

John W. Coleman,

Mark G. Buckley,

Alison Taylor,

Edwin M. Banks,

C.M.M. Williams,

M.R. Holliday,

J Thompson

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236961

Subject(s) - stem cell factor , mast cell , interleukin 33 , cytokine , biology , interleukin 5 , ionomycin , microbiology and biotechnology , mediator , immunology , stem cell , interleukin , haematopoiesis , intracellular

We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene expression in the human HMC-1 mast cell line. SCF, but not IL-4, induced low levels of serotonin release from mouse or rat peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.

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