CD40 Ligand/CD40 Deficiency | Zendy

Emanuela Castigli | Zendy; Ramsay Fuleihan | Zendy; N Ramesh | Zendy; Erdyni N. Tsitsikov | Zendy; Alla V. Tsytsykova | Zendy; Raif S. Geha | Zendy

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CD40 Ligand/CD40 Deficiency

Author(s) -

Emanuela Castigli,

Ramsay Fuleihan,

N Ramesh,

Erdyni N. Tsitsikov,

Alla V. Tsytsykova,

Raif S. Geha

Publication year - 1995

Publication title -

international archives of allergy and immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000236923

Subject(s) - cd40 , immunoglobulin class switching , isotype , immunology , antigen , biology , context (archaeology) , immunoglobulin e , antibody , b cell , monoclonal antibody , cytotoxic t cell , in vitro , genetics , paleontology

CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens.

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