Open AccessSodium Diethyl Dithiocarbamate and the Mononuclear Phagocytic System in Guinea Pigs
Author(s) -
Pierre J. Neveu,
P. Vincendeau
Publication year - 1983
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000233403
Subject(s) - dithiocarbamate , immunology , peripheral blood mononuclear cell , new guinea , guinea pig , medicine , biology , chemistry , in vitro , biochemistry , organic chemistry , history , ethnology
Sodium diethyl dithiocarbamate (DTC) is a low molecular weight sulfur compound which has been previously shown to have immunomodulatory properties. In the present report, the effects of DTC on the mononuclear phagocytic system were studied in guinea pigs. The colloidal gold clearance was enhanced in animals which received an i.v. injection of 10 mg DTC on day – 13, but not in animals treated on day – 8 with DTC. DTC treatment modified neither 99m Tc sulfur colloid uptake nor activation markers in peritoneal macrophage monolayers. These results show that DTC which modulates both delayed hypersensitivity and antibody synthesis only enhances nonspecific binding of macrophages but leaves unaffected endocytosis and metabolic status of macrophages.