Open AccessUCP3 Expression in Liver Modulates Gene Expression and Oxidative Metabolism in Response to Fatty Acids, and Sensitizes Mitochondria to Permeability Transition
Author(s) -
Yolanda Cámara,
Teresa Mampel,
Jordi Armengol,
Francesc Villarroya,
Laurent M. Dejean
Publication year - 2009
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000233249
Subject(s) - mitochondrial permeability transition pore , mitochondrion , oxidative phosphorylation , gene expression , oxidative metabolism , microbiology and biotechnology , ucp3 , uncoupling protein , oxidative damage , chemistry , oxidative stress , transition (genetics) , metabolism , biology , gene , apoptosis , endocrinology , biochemistry , programmed cell death , brown adipose tissue , adipose tissue
Uncoupling protein-3 (UCP3) is expressed in liver only under conditions of high fatty acid catabolism. However, the specific role of UCP3 in liver mitochondria and overall hepatic function is still poorly known.