Open AccessLocus 1q21 Gene Expression Changes in Atopic Dermatitis Skin Lesions: Deregulation of Small Proline-Rich Region 1A
Author(s) -
Jerzy Jarząb,
Barbara Filipowska,
Jadwiga Zebracka,
M. Kowalska,
Andrzej Bożek,
Regina Rachowska,
E Gubała,
Alicja Grzanka,
Ewa Hadas,
Barbara Jarząb
Publication year - 2009
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000232568
Subject(s) - filaggrin , loricrin , atopic dermatitis , involucrin , locus (genetics) , biology , gene expression , gene , s100a9 , candidate gene , immunology , genetics , cellular differentiation
Discovery of the significant impact of filaggrin (FLG) mutations on the genetic predisposition to atopic dermatitis (AD) focused attention on the 1q21 locus, where not only FLG but also other epidermal genes are located. In the present study, we compared 1q21 gene expression in lesional versus nonlesional AD skin.