Open AccessVascular Cell Kinetics in Response to Intimal Injury ex vivo
Author(s) -
Nina-Maria Tigerstedt,
Hanna SavolainenPeltonen,
Satu Lehti,
P Häyry
Publication year - 2009
Publication title -
journal of vascular research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000231719
Subject(s) - neointima , intimal hyperplasia , hyperplasia , neointimal hyperplasia , cell growth , vascular smooth muscle , cell , ex vivo , medicine , in vivo , pathology , microbiology and biotechnology , chemistry , biology , endocrinology , restenosis , smooth muscle , biochemistry , stent
Recent studies indicate that the smooth muscle-like cells contributing to neointimal hyperplasia after vascular injury derive from circulating precursor cells. Here, we define the time course of precursor cell influx, the roles of separate vascular layers, and the relative role of migration versus proliferation to intimal hyperplasia.