Open AccessRUNX3 Inhibits Cell Proliferation and Induces Apoptosis by TGF-β-Dependent and -Independent Mechanisms in Human Colon Carcinoma Cells
Author(s) -
Dandan Tong,
Jiang Ying,
Ming Li,
Dan Kong,
Xiang-Nin Meng,
Yanling Zhao,
Yan Jin,
Jing Bai,
Songbin Fu,
Jiao Geng
Publication year - 2009
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000218332
Subject(s) - apoptosis , cell growth , downregulation and upregulation , flow cytometry , cell cycle , transforming growth factor , signal transduction , cancer research , cell culture , biology , cell , microbiology and biotechnology , tunel assay , gene , biochemistry , genetics
Genes involved in the TGF-beta signaling pathway are often altered in several types of cancers. The TGF-beta-resistant human colon cancer cell line HT-29 has inactivated TbetaRII and deficient expression of RUNX3 and Smad4, which are involved in the TGF-beta signaling pathway.