RUNX3 Inhibits Cell Proliferation and Induces Apoptosis by TGF-β-Dependent and -Independent Mechanisms in Human Colon Carcinoma Cells | Zendy

Dandan Tong | Zendy; Ying Jiang | Zendy; Ming Li | Zendy; Dan Kong | Zendy; Xiang-nin Meng | Zendy; Yuzhen Zhao | Zendy; Yan Jin | Zendy; Jing Bai | Zendy; Songbin Fu | Zendy; Jingshu Geng | Zendy

Open Access

RUNX3 Inhibits Cell Proliferation and Induces Apoptosis by TGF-β-Dependent and -Independent Mechanisms in Human Colon Carcinoma Cells

Author(s) -

Dandan Tong,

Ying Jiang,

Ming Li,

Dan Kong,

Xiang-nin Meng,

Yuzhen Zhao,

Yan Jin,

Jing Bai,

Songbin Fu,

Jingshu Geng

Publication year - 2009

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000218332

Subject(s) - apoptosis , cell growth , downregulation and upregulation , flow cytometry , cell cycle , transforming growth factor , signal transduction , cancer research , cell culture , biology , cell , microbiology and biotechnology , tunel assay , gene , biochemistry , genetics

Genes involved in the TGF-beta signaling pathway are often altered in several types of cancers. The TGF-beta-resistant human colon cancer cell line HT-29 has inactivated TbetaRII and deficient expression of RUNX3 and Smad4, which are involved in the TGF-beta signaling pathway.

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