Open AccessCisplatin Reduces Endothelial Cell Migration Via Regulation of Type 2-Matrix Metalloproteinase Activity
Author(s) -
Mercedes Montiel,
Loredana Urso,
Blanca Esther,
Santo Marsigliante,
Eugenio Jiménez
Publication year - 2009
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000218191
Subject(s) - mapk/erk pathway , cell migration , mmp2 , chemistry , microbiology and biotechnology , matrix metalloproteinase , umbilical vein , endothelial stem cell , cisplatin , p38 mitogen activated protein kinases , human umbilical vein endothelial cell , mmp9 , phosphorylation , cell , cancer research , biology , downregulation and upregulation , biochemistry , in vitro , genetics , chemotherapy , gene
In this study we investigated the effect of cisplatin on endothelial cell migration, an essential process for vascular remodeling and regeneration in several physiological and pathological situations.