Open AccessNF-κB-Dependent Induction of Cathelicidin-Related Antimicrobial Peptide in Murine Mast Cells by Lipopolysaccharide
Author(s) -
Guiming Li,
Joanne Domenico,
Yi Jia,
Joseph J. Lucas,
Erwin W. Gelfand
Publication year - 2009
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000218115
Subject(s) - cathelicidin , mapk/erk pathway , p38 mitogen activated protein kinases , antimicrobial peptides , biology , lipopolysaccharide , innate immune system , transfection , gene expression , inflammation , nfkb1 , microbiology and biotechnology , nf κb , small interfering rna , immune system , immunology , signal transduction , gene , peptide , biochemistry , transcription factor
An important aspect of the innate immune response to pathogens is the production of anti-microbial peptides such as cathelicidin-related antimicrobial peptide (CRAMP), the murine homologue of human cathelicidin LL-37. In this study, mechanisms regulating LPS-induction of CRAMP gene expression in mast cells were investigated. NF-kappaB and MAPK pathways were the focus of investigation.