Open AccessRapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the <i>APOE </i>ε<i>4</i>/ε<i>4</i> Genotype
Author(s) -
Elin Blom,
Vilmantas Giedraitis,
Henrik Zetterberg,
Hiroaki Fukumoto,
Kaj Blennow,
Bradley T. Hyman,
Michael C. Irizarry,
LarsOlof Wahlund,
Lars Lannfelt,
Martin Ingelsson
Publication year - 2009
Publication title -
dementia and geriatric cognitive disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.026
H-Index - 110
eISSN - 1421-9824
pISSN - 1420-8008
DOI - 10.1159/000216841
Subject(s) - cerebrospinal fluid , alzheimer's disease , degenerative disease , psychology , apolipoprotein e , cognitive impairment , dementia , central nervous system disease , medicine , cognitive disorder , cognitive decline , disease , cognition , neuroscience
Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-beta42 (Abeta42) and the apolipoprotein E gene (APOE) epsilon4 allele predict progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Here, we investigated these markers to assess their predictive value and influence on the rate of disease progression.