Open AccessPositronen-Emissions-Tomographie nach Kurzinfusion von 5-[<sup>18</sup>F]Uracil: Lineares Modell für die Kinetik der <sup>18</sup>F-Radioaktivität in Tumoren
Author(s) -
Ruediger E. Port,
Ludwig G. Strauss,
John H. Clorius
Publication year - 1989
Publication title -
oncology research and treatment
Language(s) - German
Resource type - Journals
SCImago Journal Rank - 0.553
H-Index - 48
eISSN - 2296-5262
pISSN - 2296-5270
DOI - 10.1159/000216687
Subject(s) - chemistry , physics , medicinal chemistry
Patients with a colorectal malignancy were examined with a total body positron emission tomography, immediately following a brief infusion of 5-[18F]uracil. The radioactivity in normal liver tissue and in liver metastasis was monitored for two hours after infusion of the radiotracer. A kinetic model is described which permits calculation of the probable tissue concentration of 5-fluorouracil (FU) and its metabolites. Prerequisite for the model is that the time dependent plasma concentration of FU is known. It is hoped that such analysis will help predict therapeutic response, and permit evaluation of the kinetic consequences of different methods of drug application.