Open AccessPoly(ADP-Ribose) Polymerase Inhibition Down-Regulates Expression of Metastasis-Related Genes in CT26 Colon Carcinoma Cells
Author(s) -
Ming Li,
Michael D. Threadgill,
Yalan Wang,
Li Cai,
Xiao Yan Lin
Publication year - 2009
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000209388
Subject(s) - colon carcinoma , poly adp ribose polymerase , polymerase , gene , colorectal cancer , metastasis , cancer research , gene expression , biology , microbiology and biotechnology , chemistry , genetics , cancer
The current study was designed to test the hypothesis that inhibition of poly(ADP-ribose) polymerase in colorectal cancer mediates down-regulation of metastasis-related gene expression through the regulation of nuclear factor-kappaB (NF-kappaB) activity.