Open AccessBlockade of Estrogen Action Upregulates Estrogen Receptor-α mRNA in the Fetal Brain
Author(s) -
C Schaub,
Charles E. Wood
Publication year - 2009
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000208793
Subject(s) - medicine , endocrinology , fetus , estrogen receptor , estrogen , biology , western blot , messenger rna , pregnancy , biochemistry , cancer , breast cancer , gene , genetics
Fetal neuroendocrine maturation in late gestation is critical for maintenance of fetal homeostasis, growth, and readiness for birth. Sheep express estrogen receptors (ERs) in various brain regions. However, little is known about the regulation of ER-alpha and ER-beta in the ovine brain prenatally.