Corr4A and VRT325 do not Reduce the Inflammatory Response to P. aeruginosa in Human Cystic Fibrosis Airway Epithelial Cells | Zendy

Laleh Talebian | Zendy; Bonita Coutermarsh | Zendy; Jacqueline Y. Chan | Zendy; Bruce A. Stanton | Zendy

Open Access

Corr4A and VRT325 do not Reduce the Inflammatory Response to <i>P. aeruginosa</i> in Human Cystic Fibrosis Airway Epithelial Cells

Author(s) -

Laleh Talebian,

Bonita Coutermarsh,

Jacqueline Y. Chan,

Bruce A. Stanton

Publication year - 2009

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000204108

Subject(s) - cystic fibrosis , secretion , δf508 , airway , proinflammatory cytokine , lung , cystic fibrosis transmembrane conductance regulator , immunology , mucus , medicine , inflammation , biology , microbiology and biotechnology , ecology , surgery

P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to test the hypothesis that Corr4a and VRT325, investigational compounds that increase DeltaF508-CFTR mediated Cl(-) secretion in human CF airway cells, reduce the pro-inflammatory response to P. aeruginosa.

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