Open AccessThe c-src Homologue<i> Src64B</i> Is Sufficient to Activate the <i>Drosophila</i> Cellular Immune Response
Author(s) -
Michael J. Williams
Publication year - 2009
Publication title -
journal of innate immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.078
H-Index - 64
eISSN - 1662-8128
pISSN - 1662-811X
DOI - 10.1159/000191216
Subject(s) - biology , microbiology and biotechnology , haematopoiesis , immune system , population , proto oncogene tyrosine protein kinase src , innate immune system , immunology , kinase , stem cell , demography , sociology
The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.