Open AccessEnhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice
Author(s) -
Jia Guo,
Wenju Lu,
Larissa A. Shimoda,
Gregg L. Semenza,
Steve N. Georas
Publication year - 2009
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000189191
Subject(s) - ovalbumin , splenocyte , cytokine , immunology , immune system , spleen , immunoglobulin e , biology , bronchoalveolar lavage , eosinophilia , microbiology and biotechnology , endocrinology , medicine , antibody , lung
There is growing evidence that hypoxia-inducible transcription factors are involved in the pathophysiology of asthma. Hypoxia-inducible factor-1alpha (HIF-1alpha) in particular controls the expression of many hypoxia regulated genes, but whether HIF-1alpha directly contributes to allergen-driven immune responses is not known.