Enhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice | Zendy

Jia Guo | Zendy; Wenju Lu | Zendy; Larissa A. Shimoda | Zendy; Gregg L. Semenza | Zendy; Steve N. Georas | Zendy

Open Access

Enhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice

Author(s) -

Jia Guo,

Wenju Lu,

Larissa A. Shimoda,

Gregg L. Semenza,

Steve N. Georas

Publication year - 2009

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000189191

Subject(s) - ovalbumin , splenocyte , cytokine , immunology , immune system , spleen , immunoglobulin e , biology , bronchoalveolar lavage , eosinophilia , microbiology and biotechnology , endocrinology , medicine , antibody , lung

There is growing evidence that hypoxia-inducible transcription factors are involved in the pathophysiology of asthma. Hypoxia-inducible factor-1alpha (HIF-1alpha) in particular controls the expression of many hypoxia regulated genes, but whether HIF-1alpha directly contributes to allergen-driven immune responses is not known.

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