Open AccessErgic2, a Brain Specific Interacting Partner of Otoferlin
Author(s) -
Magdalena Żak,
Andreas Breß,
N. J. Brandt,
Christoph Franz,
Peter Ruth,
Markus Pfister,
Marlies Knipper,
Nikolaus Blin
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000188338
Subject(s) - neuroscience , biology , microbiology and biotechnology , medicine , computational biology , chemistry
Otoferlin, a postulated calcium sensor of 230 kDa, was proposed to trigger calcium dependent fusion of vesicles with plasma membrane in the ribbon synapses of cochlear IHCs. Otoferlin's interaction with Rab8b and Myo6, proteins involved in the intracellular membrane trafficking, extended the previous hypothesis assigning Otoferlin an additional role in trans-Golgi trafficking. Here, we present another Otoferlin binding partner, Ergic2, a protein with a still unknown function but presenting sequence homology to other proteins involved in ER/Golgi vesicle trafficking.