Open AccessIn vitroModel for Assessing Arrhythmogenic Properties of Drugs Based on High-resolution Impedance Measurements
Author(s) -
Filomain Nguemo,
Tomo Šarić,
Kurt Pfannkuche,
Manfred Watzele,
Michael Reppel,
Jürgen Hescheler
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000188069
Subject(s) - in vitro , electrical impedance , pharmacology , chemistry , medicine , physics , biochemistry , quantum mechanics
Cardiac dysfunction is one of the main cause of drug candidate failures in the preclinical and/or clinical studies and responsible for the retraction of large number of drugs from the market. The prediction of arrhythmic risk based on preclinical trials during drug development remains limited despite intensive and costly investigation. Moreover, methods for analyzing beating behavior of cardiomyocytes (CMs) in culture to diagnose arrhythmias are not well developed.