Open AccessDisparate Effects of Roscovitine on Renal Tubular Epithelial Cell Apoptosis and Senescence: Implications for Autosomal Dominant Polycystic Kidney Disease
Author(s) -
Jin Young Park,
SeeHyoung Park,
Robert H. Weiss
Publication year - 2008
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000184590
Subject(s) - apoptosis , senescence , polycystic kidney disease , autosomal dominant polycystic kidney disease , medicine , kinase , kidney , cancer research , endocrinology , cell cycle , cyclin , biology , cancer , microbiology and biotechnology , biochemistry
Control of apoptosis in autosomal dominant polycystic kidney disease (ADPKD) and in at least some cancers is likely regulated by the endogenous cyclin kinase inhibitor p21, levels of this protein being decreased in ADPKD and increased in many malignancies. The cyclin kinase inhibitor roscovitine has shown efficacy in treatment of murine PKD. We asked how a single agent can be efficacious in both PKD and cancer.