Open AccessHypoxia-Inducible Factor-1α and -2α Additively Promote Endothelial Vasculogenic Properties
Author(s) -
Jeremy Ben-Shoshan,
Sofia Maysel-Auslender,
Galia Luboshits,
Iris Barshack,
Sylvie PolakCharcon,
Eldad Tzahor,
Gad Keren,
Jacob George
Publication year - 2008
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000181546
Subject(s) - matrigel , transactivation , angiogenesis , paracrine signalling , hypoxia inducible factors , vasculogenesis , microbiology and biotechnology , chemistry , transfection , hypoxia (environmental) , cytokine , endothelial stem cell , biology , transcription factor , cancer research , immunology , in vitro , biochemistry , gene , receptor , organic chemistry , oxygen
While both play a role in the transcriptional response of hypoxic endothelial cells (ECs), hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha differ in their transactivation sites, pointing at potentially different target genes. We studied the discrete and common effects of HIF-1alpha and HIF-2alpha on the cytokine expression and vasculogenic properties of ECs.