Direct Renin Inhibition Exerts an Anti-hypertrophic Effect Associated with Improved Mitochondrial Function in Post-infarction Heart Failure in Diabetic Rats | Zendy

Rebecca ParodiRullán | Zendy; Giselle BarretoTorres | Zendy; Louis Ruiz | Zendy; José A. Casasnovas | Zendy; Sabzali Javadov | Zendy

Open Access

Direct Renin Inhibition Exerts an Anti-hypertrophic Effect Associated with Improved Mitochondrial Function in Post-infarction Heart Failure in Diabetic Rats

Author(s) -

Rebecca ParodiRullán,

Giselle BarretoTorres,

Louis Ruiz,

José A. Casasnovas,

Sabzali Javadov

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000178526

Subject(s) - aliskiren , heart failure , medicine , myocardial infarction , sirt3 , mitochondrion , ejection fraction , cardiac function curve , cardiology , endocrinology , infarction , ventricular remodeling , mitochondrial permeability transition pore , renin–angiotensin system , sirtuin , biology , apoptosis , programmed cell death , nad+ kinase , blood pressure , biochemistry , enzyme , microbiology and biotechnology

In addition to hypertension control, direct renin inhibition has been shown to exert direct beneficial effects on the heart in post-infarction cardiac remodeling. This study elucidates the possible contribution of mitochondria to the anti-hypertrophic effects of the direct renin inhibitor aliskiren in post-infarction heart failure complicated with diabetes in rats.

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