Open AccessKruppel-like Factor-15 Inhibits the Proliferation of Mesangial Cells
Author(s) -
Quan Hong,
Li Cui,
Yuansheng Xie,
Yang Lv,
Xiaoluan Liu,
Suozhu Shi,
Rui Ding,
Xueguang Zhang,
Li Zhang,
Shuwen Liu,
Xiangmei Chen
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000178518
Subject(s) - mesangial cell , cell growth , cell cycle , cyclin d1 , biology , e2f1 , cyclin a , microbiology and biotechnology , cyclin dependent kinase 2 , cell , endocrinology , kidney , biochemistry
The Kruppel-like factor-15 (KLF15), a DNA-binding transcription factor, is highly expressed in endothelial and mesangial cells of the kidney. However, its effects on mesangial cell proliferation have not previously been investigated. In this study, we investigated the effect of KLF15 on mesangial cell proliferation.