Open AccessPharmacokinetics of Protein C and Antithrombin in the Fetal Lamb: A Model to Predict Human Neonatal Replacement Dosing
Author(s) -
Marilyn J. MancoJohnson,
Michele R. Hacker,
Linda Jacobson,
William W. Hay
Publication year - 2008
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000178025
Subject(s) - pharmacokinetics , fetus , antithrombin , medicine , protein c , endocrinology , volume of distribution , biology , pregnancy , heparin , genetics
The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking.