Open AccessMesothelioma Cell Proliferation through Autocrine Activation of PDGF- �� Receptor
Author(s) -
Miki Honda,
Takeshi Kanno,
Yumiko Fujita,
Akinobu Gotoh,
Takashi Nakano,
Tomoyuki Nishizaki
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000176386
Subject(s) - platelet derived growth factor receptor , autocrine signalling , wortmannin , cell growth , cancer research , protein kinase b , microbiology and biotechnology , platelet derived growth factor , growth factor , biology , chemistry , signal transduction , receptor , biochemistry
Growth factors play a critical role in proliferation for a variety of cancer cells. The present study was conducted to understand the signaling cascades underlying PDGF-D/PDGF-ββ receptor-mediated proliferation of mesothelioma cells.