Does Body Weight Influence the Response to Intravenous Tissue Plasminogen Activator in Stroke Patients? | Zendy

Min Lou | Zendy; Magdy Selim | Zendy

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Does Body Weight Influence the Response to Intravenous Tissue Plasminogen Activator in Stroke Patients?

Author(s) -

Min Lou,

Magdy Selim

Publication year - 2008

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000175766

Subject(s) - medicine , tissue plasminogen activator , placebo , stroke (engine) , fibrinolysis , plasminogen activator , body weight , gastroenterology , acute stroke , pathology , mechanical engineering , alternative medicine , engineering

The recommended dose of IV tissue plasminogen activator (t-PA) for ischemic stroke patients weighing >100 kg (ISPW >100 kg) is fixed at 90 mg. Elevated levels of plasminogen activator inhibitor-1 (PAI-1) and impaired fibrinolysis have been reported in heavy patients, suggesting that ISPW >100 kg may require higher doses of t-PA. We hypothesized that ISPW >100 kg are less likely to benefit from IV t-PA compared to patients who weigh <or=100 kg and receive a weight-based dose.

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