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The recommended dose of IV tissue plasminogen activator (t-PA) for ischemic stroke patients weighing &gt;100 kg (ISPW &gt;100 kg) is fixed at 90 mg. Elevated levels of plasminogen activator inhibitor-1 (PAI-1) and impaired fibrinolysis have been reported in heavy patients, suggesting that ISPW &gt;100 kg may require higher doses of t-PA. We hypothesized that ISPW &gt;100 kg are less likely to benefit from IV t-PA compared to patients who weigh &lt;or=100 kg and receive a weight-based dose.

Does Body Weight Influence the Response to Intravenous Tissue Plasminogen Activator in Stroke Patients?