Open AccessMast Cell Tryptase Induces Microglia Activation via Protease-activated Receptor 2 Signaling
Author(s) -
Shu Zhang,
Xianlu Zeng,
Haiwei Yang,
Gang Hu,
Shaoheng He
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000171029
Subject(s) - tryptase , microglia , mapk/erk pathway , p38 mitogen activated protein kinases , microbiology and biotechnology , tumor necrosis factor alpha , proinflammatory cytokine , chemistry , inflammation , biology , mast cell , signal transduction , immunology
Mast cell tryptase can stimulate peripheral mononuclear cells activation to cause widespread inflammation. However, the influence of tryptase on microglia, the resident immune cells in the brain, remains uninvestigated. Since microglia plays a pivotal role in immune surveillance of CNS, we studied the effect of tryptase on microglia activation.