Open AccessMesangial Medium from IgA Nephropathy Patients Induces Podocyte Epithelial-to-mesenchymal Transition through Activation of the Phosphatidyl Inositol-3-kinase/Akt Signaling Pathway
Author(s) -
Cheng Wang,
Xun Liu,
Zun Fu Ke,
Ying Tang,
Cui Cui Li,
Can Ming Li,
Zengchun Ye,
Jun Zhang,
Tanqi Lou
Publication year - 2012
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000170949
Subject(s) - podocyte , wortmannin , protein kinase b , epithelial–mesenchymal transition , pi3k/akt/mtor pathway , microbiology and biotechnology , chemistry , endocrinology , medicine , biology , signal transduction , proteinuria , downregulation and upregulation , biochemistry , kidney , gene
Podocyte injury plays an important role in glomerulosclerosis in IgA nephropathy (IgAN). Eepithelial-to-mesenchymal transition (EMT) caused by different factors is the main reason for podocyte damage. This study hypothesized that conditioned mesangial medium may induced EMT process of podocytes and thereby lead to glomerular injury or sclerosis.