Mesangial Medium from IgA Nephropathy Patients Induces Podocyte Epithelial-to-mesenchymal Transition through Activation of the Phosphatidyl Inositol-3-kinase/Akt Signaling Pathway | Zendy

Cheng Wang | Zendy; Xun Liu | Zendy; ZunFu Ke | Zendy; Ying Tang | Zendy; Cui-Cui Li | Zendy; Can-Ming Li | Zendy; Zengchun Ye | Zendy; Jun Zhang | Zendy; Tanqi Lou | Zendy

Open Access

Mesangial Medium from IgA Nephropathy Patients Induces Podocyte Epithelial-to-mesenchymal Transition through Activation of the Phosphatidyl Inositol-3-kinase/Akt Signaling Pathway

Author(s) -

Cheng Wang,

Xun Liu,

ZunFu Ke,

Ying Tang,

Cui-Cui Li,

Can-Ming Li,

Zengchun Ye,

Jun Zhang,

Tanqi Lou

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000170949

Subject(s) - podocyte , wortmannin , protein kinase b , epithelial–mesenchymal transition , pi3k/akt/mtor pathway , microbiology and biotechnology , chemistry , endocrinology , medicine , biology , signal transduction , proteinuria , downregulation and upregulation , biochemistry , kidney , gene

Podocyte injury plays an important role in glomerulosclerosis in IgA nephropathy (IgAN). Eepithelial-to-mesenchymal transition (EMT) caused by different factors is the main reason for podocyte damage. This study hypothesized that conditioned mesangial medium may induced EMT process of podocytes and thereby lead to glomerular injury or sclerosis.

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