Open AccessNicotine Augments Glomerular Injury in a Rat Model of Acute Nephritis
Author(s) -
Edgar A. Jaimes,
Run Xia Tian,
Mahesh S. Joshi,
Leopoldo Raij
Publication year - 2008
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000163593
Subject(s) - medicine , nephritis , nicotine
Epidemiologic studies suggest that cigarette smoke worsens the progression of renal injury in patients with glomerular diseases. The mechanisms involved have not been elucidated. These studies were designed to determine whether nicotine worsens markers of inflammation including glomerular cell proliferation and fibronectin deposition in an in vivo model of glomerular injury.