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Prognosis and Natural History in the Cardiomyopathies
Author(s) -
Oakley Cm
Publication year - 1970
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000162196
Subject(s) - medicine , cardiology , hypertrophic cardiomyopathy , ventricular outflow tract , ventricular outflow tract obstruction , hemodynamics , sudden death , cardiomyopathy , outflow , natural history , heart failure , physics , meteorology
Almost 200 patients with cardiomyopathy have been studied at the Royal Postgraduate Medical School London over the last 8 years. Roughly half fell into the hypertrophic class without left ventricular dilation. Epidemiological survey has shown a familial incidence in about one third of these and a dominant mode of inheritance. Inflow restriction and sudden death predominated in this group. The sporadic cases more often showed left ventricular outflow tract obstruction and a primary role for mitral regurgitation in the genesis of this outflow obstruction has been postulated. In the sporadic group a translation from outflow to inflow obstruction sometimes occurs but seems to represent a late phase of the disorder in contrast to the familial cases in which this may be an early or sole feature. In the congestive cardiomyopathies with left ventricular dilatation a correlation between cavity dilatation and wall thickness aided assessment of prognosis the outlook being worse in those with high cavity wall thickness ratios. Coronary angiography estimations of myocardial blood flow and myocardial biopsy has been carried out in some of the patients from both groups of cardiomyopathies and the further information gained from these studies was discussed in conjunction with the physiological hemodynamic and angiographic findings in the whole series of patients with cardiomyopathy.

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