Open AccessIn vivo and T Cell Cross-Reactivity between Walnut, Cashew and Peanut
Author(s) -
Michael D. Kulis,
Laurent Pons,
A. Wesley Burks
Publication year - 2008
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000155741
Subject(s) - cross reactivity , splenocyte , in vivo , sensitization , immunoglobulin e , ovalbumin , immunology , in vitro , chemistry , biology , biochemistry , antibody , cross reactions , microbiology and biotechnology , antigen
Examination of IgE cross-reactivity among nuts has been limited to in vitro experiments. Cross-reactivity studies of nuts at the T cell level are difficult to interpret because of the inability to determine which cellular responses are from a true sensitization and which are due to cross-reactivity. Using a mouse model in which the sensitizing nuts are controlled may provide novel methods to investigate in vivo and T cell cross-reactivity.